SURG-08. COMBINED LOCAL TREATMENT OF BRAIN METASTASES: SURGERY AND POSTOPERATIVE STEREOTACTIC RADIOTHERAPY

Abstract INTRODUCTION Modern comprehensive local treatment of BM provides the possibility adequate control while maintaining a satisfactory quality life. METHODS Patients after metastasectomy and postoperative radiotherapy treated between 2007-2020 were evaluated. Local was assessed separately at site operated MM (localPFS) in other parts brain (distalPFS). RESULTS A total 118 patients enrolled (70 with WBRT), 54% women, median age 60 years, performance status Karnofsky 80%. The most common primary tumor lung carcinoma (39/118, 33%). Targeted stereotactic significantly more often indicated operations performed 2016 (p < 0.001). In period 2013-2019, gross resection achieved (83 vs 64%; p = 0.061). follow-up is 49 months. overall survival (OS) 9 months (6.2 - 12), localPFS 22 (14 unattainable), distPFS 11 (6.8 27 months), extracranialPFS (5.9 15). Stratification according to prognostic index brainmetgpa.com led significant separation for OS 0.00017). multivariate analysis, statistically positive factor compared WBRT (median 17 vs. 5.6 months, HR 0.59, 0.018) no effect on localPFS. CONCLUSION Our results are comparable presented by important foreign studies from prestigious oncology centers. We described targeted as an independent metastasectomy. study supported programme project Ministry Health Czech Republic reg. no. NV18-03-00398, NV19-03-00501 NV19-03-00559 Supported Health, Republic-conceptual development research organization (FNBr, 65269705).